| Round | Type | Opponent | For | Against | Margin | Venue | Date | |
|---|---|---|---|---|---|---|---|---|
| R1 | Away | Hawthorn | MCG | 19/03/2027 | ||||
| R2 | Home | Collingwood | Gabba | 25/03/2027 | ||||
| R3 | Away | Carlton | Docklands Stadium | 02/04/2027 | ||||
| R4 | Away | Adelaide | Adelaide Oval | 08/04/2027 | ||||
| R5 | Home | GWS Giants | Gabba | 18/04/2027 | ||||
| R6 | Home | West Coast | Gabba | 24/04/2027 | ||||
| R7 | Home | Sydney | Gabba | 29/04/2027 | ||||
| R8 | Away | Fremantle | Perth Stadium | 09/05/2027 | ||||
| R9 | Home | St Kilda | Gabba | 16/05/2027 | ||||
| R10 | Away | Port Adelaide | Adelaide Oval | 22/05/2027 | ||||
| R12 | Home | Gold Coast | Gabba | 05/06/2027 | ||||
| R13 | Away | Geelong | Kardinia Park | 11/06/2027 | ||||
| R14 | Home | Richmond | Gabba | 19/06/2027 | ||||
| R15 | Away | Sydney | SCG | 25/06/2027 | ||||
| R16 | Home | Fremantle | Gabba | 01/07/2027 | ||||
| R17 | Away | Collingwood | MCG | 05/07/2027 | ||||
| R18 | Home | North Melbourne | Gabba | 12/07/2027 | ||||
| R19 | Away | Western Bulldogs | Docklands Stadium | 19/07/2027 | ||||
| R20 | Home | Essendon | Gabba | 26/07/2027 | ||||
| R21 | Away | St Kilda | Docklands Stadium | 02/08/2027 | ||||
| R22 | Home | Geelong | Gabba | 09/08/2027 | ||||
| R23 | Away | Gold Coast | Carrara Oval | 16/08/2027 | ||||
| R24 | Away | Melbourne | MCG | 23/08/2027 |