| Round | Type | Opponent | For | Against | Margin | Venue | Date | |
|---|---|---|---|---|---|---|---|---|
| R1 | Away | Geelong | 10.9 69 | 23.9 147 | -78 | Kardinia Park | 15/03/2025 | Match stats |
| R2 | Home | Sydney | 9.11 65 | 9.14 68 | -3 | Perth Stadium | 23/03/2025 | Match stats |
| R3 | Away | West Coast | 15.16 106 | 10.8 68 | 38 | Perth Stadium | 30/03/2025 | Match stats |
| R4 | Home | Western Bulldogs | Perth Stadium | 06/04/2025 | ||||
| R5 | Away | Richmond | Barossa Park | 13/04/2025 | ||||
| R6 | Away | Melbourne | MCG | 19/04/2025 | ||||
| R7 | Home | Adelaide | Perth Stadium | 25/04/2025 | ||||
| R8 | Away | St Kilda | Docklands Stadium | 02/05/2025 | ||||
| R9 | Home | Collingwood | Perth Stadium | 08/05/2025 | ||||
| R10 | Away | GWS Giants | Sydney Showground | 17/05/2025 | ||||
| R11 | Home | Port Adelaide | Perth Stadium | 24/05/2025 | ||||
| R12 | Away | Gold Coast | Carrara Oval | 31/05/2025 | ||||
| R14 | Away | North Melbourne | Perth Stadium | 14/06/2025 | ||||
| R15 | Home | Essendon | Perth Stadium | 19/06/2025 | ||||
| R16 | Home | St Kilda | Perth Stadium | 28/06/2025 | ||||
| R17 | Away | Sydney | SCG | 04/07/2025 | ||||
| R18 | Home | Hawthorn | Perth Stadium | 11/07/2025 | ||||
| R19 | Away | Collingwood | MCG | 18/07/2025 | ||||
| R20 | Home | West Coast | Perth Stadium | 25/07/2025 | ||||
| R21 | Home | Carlton | Perth Stadium | 01/08/2025 | ||||
| R22 | Away | Port Adelaide | Adelaide Oval | 08/08/2025 | ||||
| R23 | Home | Brisbane | Perth Stadium | 15/08/2025 | ||||
| R24 | Away | Western Bulldogs | Docklands Stadium | 22/08/2025 |