| Round | Type | Opponent | For | Against | Margin | Venue | Date | |
|---|---|---|---|---|---|---|---|---|
| R1 | Home | Gold Coast | 7.7 49 | 20.16 136 | -87 | Perth Stadium | 16/03/2025 | Match stats |
| R2 | Away | Brisbane | 11.9 75 | 14.10 94 | -19 | Gabba | 23/03/2025 | Match stats |
| R3 | Home | Walyalup | 10.8 68 | 15.16 106 | -38 | Perth Stadium | 30/03/2025 | Match stats |
| R4 | Away | GWS Giants | 7.9 51 | 20.12 132 | -81 | Sydney Showground | 06/04/2025 | Match stats |
| R5 | Away | Carlton | 6.14 50 | 17.19 121 | -71 | Adelaide Oval | 12/04/2025 | Match stats |
| R6 | Home | Essendon | 11.9 75 | 11.11 77 | -2 | Perth Stadium | 18/04/2025 | Match stats |
| R7 | Away | Hawthorn | 11.8 74 | 18.16 124 | -50 | Docklands Stadium | 27/04/2025 | Match stats |
| R8 | Home | Narrm | 11.10 76 | 16.12 108 | -32 | Perth Stadium | 03/05/2025 | Match stats |
| R9 | Away | Richmond | 11.13 79 | 11.15 81 | -2 | MCG | 11/05/2025 | Match stats |
| R10 | Home | Euro-Yroke | 16.12 108 | 12.8 80 | 28 | Perth Stadium | 18/05/2025 | Match stats |
| R11 | Away | Kuwarna | 8.14 62 | 19.14 128 | -66 | Adelaide Oval | 25/05/2025 | Match stats |
| R12 | Home | Geelong | Perth Stadium | 01/06/2025 | ||||
| R13 | Away | North Melbourne | Hands Oval | 08/06/2025 | ||||
| R14 | Home | Carlton | Perth Stadium | 15/06/2025 | ||||
| R16 | Away | Collingwood | Docklands Stadium | 28/06/2025 | ||||
| R17 | Home | GWS Giants | Perth Stadium | 04/07/2025 | ||||
| R18 | Away | Yartapuulti | Adelaide Oval | 13/07/2025 | ||||
| R19 | Home | Richmond | Perth Stadium | 19/07/2025 | ||||
| R20 | Away | Walyalup | Perth Stadium | 26/07/2025 | ||||
| R21 | Away | Narrm | Docklands Stadium | 02/08/2025 | ||||
| R22 | Home | Kuwarna | Perth Stadium | 10/08/2025 | ||||
| R23 | Away | Western Bulldogs | Docklands Stadium | 17/08/2025 | ||||
| R24 | Home | Sydney | Perth Stadium | 22/08/2025 |