| Round | Type | Opponent | For | Against | Margin | Venue | Date | |
|---|---|---|---|---|---|---|---|---|
| R1 | Home | Gold Coast | 7.7 49 | 20.16 136 | -87 | Perth Stadium | 16/03/2025 | Match stats |
| R2 | Away | Brisbane | 11.9 75 | 14.10 94 | -19 | Gabba | 23/03/2025 | Match stats |
| R3 | Home | Fremantle | 10.8 68 | 15.16 106 | -38 | Perth Stadium | 30/03/2025 | Match stats |
| R4 | Away | GWS Giants | Sydney Showground | 06/04/2025 | ||||
| R5 | Away | Carlton | Adelaide Oval | 12/04/2025 | ||||
| R6 | Home | Essendon | Perth Stadium | 18/04/2025 | ||||
| R7 | Away | Hawthorn | Docklands Stadium | 27/04/2025 | ||||
| R8 | Home | Melbourne | Perth Stadium | 03/05/2025 | ||||
| R9 | Away | Richmond | MCG | 11/05/2025 | ||||
| R10 | Home | St Kilda | Perth Stadium | 18/05/2025 | ||||
| R11 | Away | Adelaide | Adelaide Oval | 25/05/2025 | ||||
| R12 | Home | Geelong | Perth Stadium | 01/06/2025 | ||||
| R13 | Away | North Melbourne | Hands Oval | 08/06/2025 | ||||
| R14 | Home | Carlton | Perth Stadium | 15/06/2025 | ||||
| R16 | Away | Collingwood | Docklands Stadium | 28/06/2025 | ||||
| R17 | Home | GWS Giants | Perth Stadium | 04/07/2025 | ||||
| R18 | Away | Port Adelaide | Adelaide Oval | 11/07/2025 | ||||
| R19 | Home | Richmond | Perth Stadium | 18/07/2025 | ||||
| R20 | Away | Fremantle | Perth Stadium | 25/07/2025 | ||||
| R21 | Away | Melbourne | Docklands Stadium | 01/08/2025 | ||||
| R22 | Home | Adelaide | Perth Stadium | 08/08/2025 | ||||
| R23 | Away | Western Bulldogs | Docklands Stadium | 15/08/2025 | ||||
| R24 | Home | Sydney | Perth Stadium | 22/08/2025 |